The research in our laboratory focuses on the development of synthetic methods and strategies for preparation of structurally non-trivial small molecules for applications in biomedical research:

  • selective kinase inhibitors
  • modulators of adenylyl cyclases
  • inhibitors of  DNA repair pathways
  • small molecule probes of cell differentiation
  • fluorescent probes for biological systems


Latest publications

Amaro, M.; Brezovský, J.; Kováčová, S.; Sýkora, J.; Bednář, D.; Němec, V.; Lišková, V.; Kurumbang, N.; Beerens, K.; Chaloupková, R.; Paruch, K.; Hof, M.; Damborský, J. Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence. J. Am. Chem. Soc. 2015 DOI: 10.1021/jacs.5b01681, abstract.

Maier, L.; Hylse, O.; Nečas, M.; Trbušek, M.; Ytre-Arne, M.; Dalhus, B.; Bjorås, M.; Paruch, K.New Carbocyclic Nucleosides: Synthesis of Carbocyclic Pseudoisocytidine and its Analogs. Tetrahedron Lett. 2014, 55, 3713, abstract.

Amaro, M.; Brezovsky, J.; Kovacova, S.; Maier, L.; Chaloupkova, R.; Sykora, J.; Paruch, K.; Damborsky, J.; Hof, M. Are Time-Dependent Fluorescence Shifts at the Tunnel Mouth of Haloalkane Dehalogenase Enzymes Dependent on the Choice of the Chromophore? J. Phys. Chem. B 2013, 117, 7898, abstract.

Brahmkshatriya, P. S.; Dobes, P.; Fanfrlik, J.; Rezac, J.; Paruch, K.; Bronowska, A.; Lepsik, M.; Hobza, P. Quantum Mechanical Scoring: Structural and Energetic Insights into Cyclin-Dependent Kinase 2 Inhibition by Pyrazolo[1,5-a]pyrimidines Curr. Comput. Aided Drug Des. 2013, 9, 118-129, abstract.