Our reserach: Inhaled Lead Nanoparticles Enter the Brain through the Olfactory Pathway and Induce Neurodegenerative Changes Resembling Tauopathies
The long-term cooperation of the Atomic Spectroscopy Laboratory group with the scientific groups of Prof. Buchtová, MUDr. Dumková and Dr. Mikuška resulted in another publication, which was published in the prestigious journal ACS Nano. They participated in the discovery that inhalation of lead-based nanoparticles leads, among other things, to neurodegenerative brain damage, because the nanoparticles enter the brain directly through the olfactory pathway.
The results published in ACS Nano demonstrated that inhaled lead nanoparticles penetrate the brain via the olfactory pathway. In brain, they induce changes resembling damage seen in neurodegenerative diseases. This represents the first conclusive evidence of this mechanism in mammals, significantly expanding the understanding of the neurotoxicity of metallic nanoparticles.
JEDLIČKOVÁ, Adriena; Daniela KRISTEKOVÁ; Zuzana HUSÁKOVÁ; Pavel COUFALÍK; Lucie VRLÍKOVÁ; Tereza SMUTNÁ; Michaela CAPANDOVÁ; Lukáš ALEXA; Denisa LUSKOVÁ; Kamil KŘŮMAL; Veronika JAKEŠOVÁ; Zbyněk VEČEŘA; Nikodém ZEZULA; Viktor KANICKÝ; Aleš HAMPL; Tomáš VACULOVIČ; Pavel MIKUŠKA; Jana DUMKOVÁ a Marcela BUCHTOVÁ. Inhaled Lead Nanoparticles Enter the Brain through the Olfactory Pathway and Induce Neurodegenerative Changes Resembling Tauopathies. ACS Nano. WASHINGTON: AMER CHEMICAL SOC, 2025, roč. 19, č. 13, s. 12799-12826. ISSN 1936-0851. https://dx.doi.org/10.1021/acsnano.4c14571.